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Senior Director / Vice President, Chemistry

SiteOne Therapeutics

SiteOne Therapeutics

Sales & Business Development
South San Francisco, CA, USA
Posted on Monday, January 22, 2024

About SiteOne

SiteOne Therapeutics is a biopharmaceutical company developing treatments for hypersensitivity disorders of the nervous system such as pain, cough and epilepsy. Our values are scientific rigor, intensity, teamwork and commitment to our shared mission of developing transformative medicines for the benefit of patients. Our drug candidates are exquisitely selective modulators of ion channels, and are under investigation by both systemic and local routes of administration. An opportunity is currently available for an exceptionally talented and highly motivated scientist to lead our growing chemistry team at our South San Francisco laboratory. On-site and hybrid options are available.

To apply, please email a CV and Research Summary to apply@site1therapeutics.com


· Build and lead the medicinal chemistry functional area, including internal and external FTEs and other resources

· Drive cross-functional project teams to achieve key research milestones such as lead identification, in vivo proof of concept, and development candidate nomination

· Manage PhD level scientists to a high level of productivity while improving the skills and knowledge of junior colleagues through mentoring

· Institute best practices in the management of compounds and compound data collections

· Maintain an acute awareness of the competitive landscape by regularly monitoring published patent applications, meeting abstracts and scientific literature

· Execute an intellectual property strategy to achieve broad coverage of key compounds while taking into account the competitiveness of the space

· Manage external teams of scientists to achieve early process chemistry milestones such as scale up for toxicology and IND-enabling development

· Communicate regular project status updates to the executive team and key stakeholders


· A PhD or equivalent with a focus on organic/medicinal chemistry

· 12+ years of relevant post-degree work experience in medicinal chemistry

· Experience leading project teams that have successfully advanced candidate molecules to at least early clinical development

· A strong understanding of and ability to work with pharmacological, physicochemical, ADME and pharmacokinetic data to make technically-sound decisions around compound design

· Experience with structure-based and property-based strategies for lead optimization

· Familiarity with chemoinformatic tools, databases and best practices for compound data management

· An outstanding track record of peer-reviewed publications and patent applications that demonstrates technical proficiency, scientific creativity, initiative and the ability to collaborate with others

· Excellent teamwork, organizational and interpersonal skills


A highly competitive base salary, equity, bonus potential, 401(k), medical, dental, vision, and paid time off are among the benefits of the position.